Somasish Profile pic 2020.jpg

Published Work

References and Links to Papers in Aging and age related disorders

4E-BP1; alpha-synuclein; mitochondrial unfolded protein response; neuroprotection; Parkinson’s disease; protein translation

2020

4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response.

Somasish Ghosh Dastidar*, Michael T. Pham, Matthew B. Mitchell, Steven G. Yeom, Sarah Jordan, Angela Chang, Bryce L. Sopher and Albert R. La Spada). * Co corresponding Author.

Journal of Neuroscience.  4 November 2020, 40 (45) 8734-8745; DOI: https://doi.org/10.1523/JNEUROSCI.0940-20.2020 

ALS; dipeptide-repeat (DPR) proteins; C9ORF72; Autophagy; Transgenic mice.

2020

Reduced C9ORF72 Function Exacerbates Gain of Toxicity From ALS/FTD-causing Repeat Expansion in C9orf72.

Qiang Zhu, Jie Jiang, Tania F Gendron, Melissa McAlonis-Downes, Lulin Jiang, Amy Taylor, Sandra Diaz Garcia, Somasish Ghosh Dastidar, Maria J Rodriguez, Patrick King, Yongjie Zhang, Albert R La Spada, Huaxi Xu, Leonard Petrucelli, John Ravits, Sandrine Da Cruz, Clotilde Lagier-Tourenne, Don W Cleveland

Nature Neuroscience. 2020 May;23(5):615-624.

 doi: 10.1038/s41593-020-0619-5. Epub 2020 Apr 13

PMID: 32284607

DOI: 10.1038/s41593-020-0619-5

Aging; Heart failure; Nutrient signaling; Proteomics; mTOR

2019

Differential Effects of Various Genetic Mouse Models of the Mechanistic Target of Rapamycin Complex I Inhibition on Heart Failure.

Dao-Fu Dai, Yonggang Liu, Nathan Basisty, Pabalu Karunadharma, Somasish G Dastidar, Ying Ann Chiao, Tony Chen, Richard P Beyer, Michael T Chin, Michael Maccoss, Albert R La Spada, Peter S Rabinovitch.

Geroscience. 2019 Dec;41(6):847-860.

 doi: 10.1007/s11357-019-00119-6. Epub 2019 Oct 24.

PMID: 31650481.PMCID: PMC6925086.

DOI: 10.1007/s11357-019-00119-6

FUS; RNA metabolism; amyotrophic lateral sclerosis (ALS); autophagy-lysosome; frontotemporal degeneration (FTD); homeostasis.

2019

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.

Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, M Tse Tsemay, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland.

Elife. 2019 Feb 12;8:e40811.

PMID: 30747709. PMCID: PMC6389288. DOI: 10.7554/eLife.40811

Amyotrophic lateral sclerosis; Gene targeting; Motor neuron; Neurodegeneration; Nucleocytoplasmic transport; Ran; RanGAP1; Senataxin; TDP-43; Transgenesis.

2018

Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.

Craig L Bennett*, Somasish G Dastidar*, Shuo-Chien Ling, Bilal Malik, Travis Ashe, Mandheer Wadhwa, Derek B Miller, Changwoo Lee, Matthew B Mitchell, Michael A van Es, Christopher Grunseich, Yingzhang Chen, Bryce L Sopher, Linda Greensmith, Don W Cleveland, Albert R La Spada

Acta Neuropathologica. 2018. Sep;136(3):425-443.Epub 2018 May 3.

PMID: 29725819. PMCID: PMC6098723. DOI: 10.1007/s00401-018-1852-9

* Denotes Equal Contribution.

Diet-Induced Obesity; Insulin Resistance; 4EBP1; skeletal muscle; Adipose tissue; Transgenic mice. 

2016

Increased 4E-BP1 expression protects against diet-induced obesity and insulin resistance in male mice.

Shih-Yin Tsai, Ariana A Rodriguez, Somasish G Dastidar, Elizabeth Del Greco, Kaili Lia Carr, Joanna M Sitzmann, Emmeline C Academia, Christian Michael Viray, Lizbeth Leon Martinez, Brian Stephen Kaplowitz, Travis D Ashe, Albert R La Spada, Brian K Kennedy.

Cell Reports. 2016 Aug 16;16(7):1903-14. Epub 2016 Aug 4.

PMID: 27498874. PMCID: PMC4988876. DOI: 10.1016/j.celrep.2016.07.029

Aging and Obesity; Skeletal muscle;  mTOR; 4EBP1; diet-induced insulin resistance; Transgenic mice. 

2015

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

Shihyin Tsai, Joanna M Sitzmann, Somasish G Dastidar, Ariana A Rodriguez, Stephanie L Vu, Circe E McDonald, Emmeline C Academia, Monique N O’Leary, Travis D Ashe, Albert R La Spada, Brian K Kennedy.

The Journal of Clinical Investigation. 2015 Aug 3;125(8):2952-64. Epub 2015 Jun 29.

PMID: 26121750. PMCID: PMC4563739.DOI: 10.1172/JCI77361

Nutrient homeostasis; Proteostasis regulation; Let7; mTOR, MAP4K3; Neuronal Autophagy.

2014

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.

Amy N Dubinsky*, Somasish Ghosh Dastidar*, Cynthia L Hsu*, Rabaab Zahra*, Stevan N Djakovic, Sonia Duarte, Christine C Esau, Brian Spencer, Travis D Ashe, Kimberlee M Fischer, Deidre A MacKenna, Bryce L Sopher, Eliezer Masliah, Terry Gaasterland, B Nelson Chau, Luis Pereira de Almeida, Bradley E Morrison, Albert R La Spada.

Cell Metabolism. 2014 Oct 7;20(4):626-38.

PMID: 25295787. PMCID: PMC4245205. DOI: 10.1016/j.cmet.2014.09.001.

*Indicates equal contribution.

Neuronal Apoptosis; Neuronal survival; TLE1; FoxG1; Pharmacological inhibitors; PI3K-Akt; Transcription.

2012

Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.

Somasish Ghosh Dastidar, Sriram Narayanan, Stefano Stifani, Santosh R D'Mello.

Journal of Biological Chemistry. 2012 Apr 27;287(18):14749-59. Epub 2012 Feb 21.

PMID: 22354967. PMCID: PMC3340250.DOI: 10.1074/jbc.M111.328336

Neurodevelopmental disorder; Rett syndrome;  MeCP2; FoxG1; Neuronal apoptosis; IGF-1.

2012

Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1.

Somasish Ghosh Dastidar, Farah H Bardai, Chi Ma, Valerie Price, Varun Rawat, Pragya Verma, Vinodh Narayanan, Santosh R D'Mello.

Journal of Neuroscience. 2012 Feb 22;32(8):2846-55.

PMID: 22357867. PMCID: PMC3403752.DOI: 10.1523/JNEUROSCI.5841-11.2012

Transcription factor, Neuronal Survival; Postmitotic Neurons; FoxG1; Rett-like Syndrome; IGF-1/Akt signaling.

2011

FoxG1 promotes the survival of postmitotic neurons. 

Somasish Ghosh Dastidar, Paul Michael Zagala Landrieu, Santosh R D'Mello.

Journal of Neuroscience. 2011 Jan 12;31(2):402-13.

PMID: 21228151. PMCID: PMC4640444. DOI: 10.1523/JNEUROSCI.2897-10.2011